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That single chemical addition converts a brief, pulsatile GHRH stimulus into week-long GH and IGF-1 elevation, with once-weekly dosing in human trials versus the multiple daily administrations the no-DAC core's minutes-scale half-life would demand

H., Santos, L

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While moderate weight reduction is often therapeutically beneficialparticularly in improving metabolic disorders such as type 2 diabetes and obesitysubstantial or prolonged weight loss has been increasingly implicated in adverse skeletal outcomes